GLOWBIOTICS PROBIOTIC SKINCARE MD

 HOW IS OUR PROBIOTIC TECHNOLOGY DIFFERENT?

 GLOWBIOTICS products contain a range of ingredients and formulations that specifically target the health of the skin while avoiding the utilization of harsh chemicals and unhealthy ingredients that are often included in anti-aging and skin health products/treatments. Our products have a clean profile and are infused with a potent blend of probiotics, antioxidants and nutrients that utilize unique delivery systems and specific technologies that deliver proven results. 

 PROBIOTIC DERIVED BIOACTIVES (PDBS)

 The skin is a remarkable organ that comprises the second largest structure of our body's immune system. A significant portion of the skin's immune system, just like our gut, consists of the residence of mostly beneficial bacteria that sit on the surface of the skin, acting as its first line of environmental defense. This is the skin's microbiome. When the microbiome ecosystem is off balance, our skin becomes more susceptible to invading pathogens, environmental aggressors and premature aging. When Probiotic Derived Bioactives, produced when body friendly bacteria is put through a special fermentation process, are applied to the skin, a myriad of beneficial skin health pathways are stimulated. They alter the skin's ratio of commensal-to-pathogenic microorganisms. They increase skin barrier integrity while optimizing collagen and elastin levels. They also decrease negative responses in the skin, making PDBs remarkable in their ability to drastically improve the health and appearance of all skin types. Bonicel (Bacillus Ferment, Lactococcus Ferment Lysate, Lactobacillus/Saccharomyces/Rice/Sucrose Ferment Filtrate, Rice/Saccharomyces Lyce/Lactobacillus Ferment Filtrate, and Lactobacillus Ferment are the different strains of probiotics found in GLOWBIOTICS products. 

 SMART RETINOID (GLYCERYL DIRETINOATE/GDR)

 While globally accepted as the most important vitamin for the health of the skin, from an anti-aging perspective, vitamin A, or retinoids as they are commonly known, have some inherent flaws when used in the forms widely available including irritation, redness, excessive flaking, and sun sensitivity - just to name a few. The bioactive form of retinoid that gets utilized by the cell is tretinoin, or retinoic acid. However, when applied topically in this pure form, it completely destroys the skin's protective barrier and activates inflammatory pathways. Patented and exclusive to GLOWBIOTICS, glyceryl diretinoate (GDR) solves these problems. GDR is the byproduct of the reaction of retinoic acid with glycerin. What is produced is a retinoic acid ester, or retinoic acid attached to a triglyceride (think liposome-coated). This stabilizes the retinoid, increases its lipophilic properties and reduces its irritation profile. When applied to skin, GDR is readily absorbed by the stratum corneum. Once at the target site (DEJ), simple lipase enzymes will cleave the molecule releasing the free retinoic acid species to be absorbed by the cell, all while barrier integrity is maintained. The ultimate, smart, high-performance retinoid, with none of the irritation. 

 SMART PEPTIDES (LIPO-OLIGOPEPTIDES)

 Peptides are the building blocks of proteins and the majority of all live tissue. Peptides are comprised of amino acid chains strung together in different arrangements and they work at the cellular level to increase cell-to-cell communication, or cross talk. Functioning as neuromodulators, neurotransmitters and even hormones, these powerful pharmacologically-active molecules are of great interest and proven to have a great benefit to cosmetic manufacturers and medicine as a whole. Operating at the receptor site of the cell, peptides work in a sort of a lock and key fashion. The peptide being the "key," and the receptor of interest on the surface of the cell the "lock". Once "lock" and "key" meet up, it signals the nucleus of the cell to cause a change in genetic expression, which will release messenger molecules from the cell to all neighboring cells. Skin communication has now begun. GLOWBIOTICS utilizes a variety of lipo-oligopeptides, peptides with fatty acids attached for better delivery, designed for a variety of specific functions. 

 DNA/MICROARRAY ASSAY TESTING

 GLOWBIOTICS is one of the first medical skincare companies to pioneer the use of DNA microarray assay technology to take clinical validation to the next level. The development of this technology is the most significant advancement in cellular biology since the discovery of DNA. Here is the process, simplified: cultured human dermal fibroblasts and epidermal keratinocytes are grown in 3D suspension to mimic the complete skin model. An active ingredient, or final formulation is applied to this tissue for a specific period of time to achieve a desired response, at this stage being differentiation and proliferation. At this point, those cells are removed and the RNA is extracted from the cells and placed on the microarray panel - a measuring device with different genetic markers and variants attached. Once applied, we can now see if the genetic markers are turned on (up-regulated) or turned off (down-regulated).